In the last post we discussed a breakthrough in the way we understand ADMA, metformin, and mTOR regulation in fetal development, health, aging, and chronic illness. There is another critical insight that comes from this new research. You know now that the master genetic metabolic switch mTOR is vital to coordinate food availability with growth in the fetus. mTOR has a reciprocal relationship with another master metabolic genetic switch called AMPK. When food is widely available, mTOR is switched on, and AMPK is switched off. When food is scarce, mTOR is switched off and AMPK is switched on to break down fat and muscle to produce enough energy to promote fetal survival. This is one of the key relationships in developmental human biology that maximizes growth in good times and survival in bad times. Like mTOR, AMPK regulates dozens of genes as you can see here.
The ADMA-metformin interaction is the key to the mTOR-AMPK relationship. Metformin and ADMA neutralize each other at the level of a cellular membrane. Metformin, independent of AMPK, directly inhibits mTOR by blocking the effect of the amino acid ADMA to switch on mTOR via an amino acid sensing mechanism. Metformin directly switches off AMPK by the same mechanism. Here is more detail on the amino acid sensing mechanism. The ADMA metformin relationship is a key to better understanding development, aging, and chronic illness. This relationship is a new understanding of the mechanism of action for metformin. Medications like empagliflozin also switch on AMPK.
Employers must demand OMT as part of their CAA fiduciary duty.......it will produce more predictable costs and outcomes and reduce catastrophic risk in their plans.
This is why intermittent fasting can lead to better cellular functions.