In diabetes, we have traditionally thought of microvascular disease as affecting the eyes, the nerves, and the kidney. It is becoming very clear at the level of epigenetics, molecular biology and microvascular disease that the complications of diabetes, vascular disease, and aging itself are all related. “An intriguing unifying hypothesis suggests that microvascular dysfunction of specific organs is an expression of a systemic illness that worsens with age and is accelerated by vascular risk factors…. It is our premise that the pathophysiology of small vessel disease in the brain is similar to small vessel disease in other heavily perfused tissues and that the presence of small vessel disease elsewhere in the body foretells its presence in the brain as well as its consequences on cognitive function. The hypothesis presented in this article is that small vessel disease is a systemic condition of aging that is exacerbated by vascular risk factors, which results from dysfunction of arteriolar perfusion.”
This microvascular disease impacts all organs and tissues. It is characterized by reduced ability to dilate tiny arteries and clots in these tiny vessels. These small arteries show remodeling and an impaired ability to regulate themselves. The capillaries in organ tissues are damaged leading to poor nutrient and oxygen supply and impaired organ function. In the brain microvascular disease causes stroke, vascular dementia, depression, and anxiety. It is a contributing factor in up to 45% of cases of dementia. Chronic kidney disease (CKD) is a common condition affecting 20 million Americans. It is caused by capillary destruction, reduced arteriole reaction to a need for more flow, and scarring leading to progressive loss of kidney function. The back of the eye is unique in that blood vessels can be directly visualized allowing us to see changes of the microvascular disease. Inflammation, scarring, swelling, growth of tiny new vessels with bleeding, and capillary degeneration results in retinopathy and associated vision loss. Microvascular disease plays a prominent role in peripheral artery disease leading to amputation. High blood pressure in the lung arteries caused by microvascular disease leads to increased vascular resistance, progressive right heart failure and death.
Death and disability due to cardiovascular and related conditions like high blood pressure and diabetes are caused by the whole body problem of disease of the large and small arteries. Both are involved at the same time. That is yet another reason that opening the large arteries does not reduce vascular events and death in stable patients. It is yet another reason that we must move away from a focus on individual organs and risk factors to a whole body approach to cardiovascular conditions. How can we delay forming advanced primary care teams focus on these chronic illnesses any longer? It is time to make the needed reforms!
Yup! I have known this for at least two decades. By adopting early detection of Cardiometabolic disease and instituting effective individualized primary lifestyle optimization prevention measures, we not only reverse the impact of the metabolic dysfunctions to the cardiovascular diseases, we also reverse diseases affecting the entire system! People live longer and healthier for a fraction of their lifetime costs of care.
There are some saying that damages from the C jab given without aspiration are leading to a bolus delivery of the vax directly into the vascular system leading to damage to the major epithelial walls which then includes the micro vascular walls. Little aspiration is happening here in the USA. Marc Girodot Substack. Not sure I have his last name right but his articles on the epithelium are fascinating if not alarming.