In the last post, I discussed my struggle in the aftermath of cancer treatment and the role of senescent (senile/old) cells induced by chemotherapy and radiation. There is an entirely new body of science that can help us deal with the continuing damage from cancer treatment. This body of science applies to aging and chronic disease more generally as well. It has real, practical application now and it is not that difficult. Senescent cells are one piece of a much bigger answer. There are all kinds of proposed isolated solutions to prolong our healthy lives. That is not the answer. Living longer and slowing the aging process requires a combination of diet, exercise, and specific medications.
We have previously discussed the way that lisinopril or losartan and spironolactone or eplerenone for high blood pressure, statins for cholesterol, and metformin for type 2 diabetes are all antioxidants that block the effects of inappropriately activated genes to slow the development of chronic diseases and aging generally. These same medications also slow down the develoment of senescent cells that reduce the inflammation and growth factors that they produce.
Lisinopril and losartan interfere with the effects of a hormone that causes cells in the arteries and kidneys to become senescent and produce inflammation and growth factors. Metformin blocks the effects of an epigenetic product to slow formation of senescent cells and the inflammation that goes with it. Spironolactone and eplerenone block the effects of aldosterone and cortisone to accomplish the same thing. Aldosterone production increases with aging and is not as well regulated creating a vicious cycle. Statins also block the formation of senescent cells and the consequences of that transformation. This is an entirely new body of science that shows lowering the blood pressure, blood sugar, and cholesterol is important, but the way they are lowered is even more important. These medicines in combination slow the development of senescent cells and the chronic diseases and more rapid aging that these cells produce. You can enjoy the benefits of this new science now!
Both of your posts on chronic illness have been greatly appreciated, Bill - Thanks!
Fascinating.