Interventions that slow aging and prevent chronic diseases more than would be expected based on the impact on the target risk factor switch on the master metabolic genetic switch AMPK and switch off mTOR. That seems to be the common denominator. Olive oil is no exception. The main polyphenol in extra virgin olive oil switches on AMPK and switches off mTOR. That is likely to be the major metabolic mechanism underlying the beneficial effects of polyphenols.
Natural polyphenols from certain foods are protective against a wide number of human illnesses from neurodegenerative to cardiovascular diseases, cancer and diabetes, including ageing. These include compounds such as resveratrol, epigallocatechin-3-gallate (EGCG), curcumin, morin, quercetin and oleuropein aglycone (OLE) found in a number of foods of plant origin and believed to be at the basis of the claimed beneficial properties of these foods. These benefits seem to be on the basis of their anti-oxidant and anti-inflammatory properties. Switching on AMPK and switching off mTOR seems to be the core metabolic factor common to the benefits of these polyphenols.
Switching on AMPK and swithing off mTOR seems to be the common denominator by which polyphenols in foods, caloric restriction, intermittent fasting, exercise, lisinopril, losartan, statins, spironolactone, metformin, and empagliflozin slow aging and delay chronic illnesses. Optimal medical therapy combines all of these interventions to help us stay healthy longer.
Yup. Absolutely!
I am fortunate not to have cholesterol, BP, DMII issues. And I am not fond of Olive oil. I'll find a way to make it palatable for myself.
I am passing your posts on to friends, hoping they subscribe.
I don't know if I have mentioned it before, but a book of your essays, perhaps further extended, would be great.