This Article Shows How Blocking Aldosterone Protects Cells and Organs
williamhbestermannjrmd.substack.com
This diagram from this article was the first that showed me medications that protect cells and organs are better than those that merely lower the target risk factor. It is all in the picture. Aldosterone activates MR (mineralocorticoid receptor). Corticol generated by stress or fear does the same thing. MR activation increases reactive oxygen species (ROS) generation or oxidants which directly activate the epidermal growth factor receceptor (EGFR). That activates further signaling cascades which ultimately switch on the master metabolic switch on mTOR and switch off AMPK. That causes mesangial cell growth which is an important part of chronic kidney disease. Spironolactone, eplerenone, and the new
This Article Shows How Blocking Aldosterone Protects Cells and Organs
This Article Shows How Blocking Aldosterone…
This Article Shows How Blocking Aldosterone Protects Cells and Organs
This diagram from this article was the first that showed me medications that protect cells and organs are better than those that merely lower the target risk factor. It is all in the picture. Aldosterone activates MR (mineralocorticoid receptor). Corticol generated by stress or fear does the same thing. MR activation increases reactive oxygen species (ROS) generation or oxidants which directly activate the epidermal growth factor receceptor (EGFR). That activates further signaling cascades which ultimately switch on the master metabolic switch on mTOR and switch off AMPK. That causes mesangial cell growth which is an important part of chronic kidney disease. Spironolactone, eplerenone, and the new