The last post was about Dr. David Sinclair and his work on slowing and even reversing aging at Harvard. This video lasts just 6 short minutes, but it is very instructive regarding lifestyle measures that prolong healthy life. Most intriguingly to me, he mentions a unified hypothesis of aging. I would modify his assessment to broaden it to a unified hypothesis of aging and chronic disease. Chronic diseases and aging are related at the deepest level. The core of these challenges is epigenetics and related signaling that feed into the master metabolic switches mTOR and AMPK as Dr. Sinclair explained in the last post.
Do we know how much metformin is effective for its anti aging property. Does one need a full 500mg/day dose? Will 250 mg suffice to achieve pro AMPK activity?
Do we know how much metformin is effective for its anti aging property. Does one need a full 500mg/day dose? Will 250 mg suffice to achieve pro AMPK activity?
Amazing and thank you for discussing this topic.