The last post was about Dr. David Sinclair and his work on slowing and even reversing aging at Harvard. This video lasts just 6 short minutes, but it is very instructive regarding lifestyle measures that prolong healthy life. Most intriguingly to me, he mentions a unified hypothesis of aging. I would modify his assessment to broaden it to a unified hypothesis of aging and chronic disease. Chronic diseases and aging are related at the deepest level. The core of these challenges is epigenetics and related signaling that feed into the master metabolic switches mTOR and AMPK as Dr. Sinclair explained in the last post.
Do we know how much metformin is effective for its anti aging property. Does one need a full 500mg/day dose? Will 250 mg suffice to achieve pro AMPK activity?
Most think of metformin as a glucose-lowering medicine. I think it impacts the key signaling pathways at lower doses. I have prediabetes and I take 500mg twice a day. I have no side effects at all.
Do we know how much metformin is effective for its anti aging property. Does one need a full 500mg/day dose? Will 250 mg suffice to achieve pro AMPK activity?
Most think of metformin as a glucose-lowering medicine. I think it impacts the key signaling pathways at lower doses. I have prediabetes and I take 500mg twice a day. I have no side effects at all.
https://www.nature.com/articles/s41586-022-04431-8
I do not have prediabetes. I hope to persuade my PCP to order it for me. We shall see as it would be for an “off label” indication.
That makes sense. Good luck
Amazing and thank you for discussing this topic.
The promise of new scientific discoveries is amazing. Thanks for your help