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William H Bestermann Jr MD's avatar

This is for mcgdoc. We understand aging well enough to prolong healthy human life by 8 years as the link at the bottom proves. My best analysis of that study is that epigenetics related to environmental factors like obesity and smoking activate molecular biology that makes us age and become ill faster. Optimal medical therapy blocks that molecular biology. Aging is not just a matter of wearing out. We don't wear out like an old shoe. You can see this all around us. Some mammals live a year. Some mammals live 250 years. That is because their genes and molecular biology are different.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506099/

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Kevin's avatar

I keep coming up with the same conclusion every time I read Dr. B.’s posts: medicate with metformin, statins, etc. whether one has a diagnosis or not.

Please set me straight.

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William H Bestermann Jr MD's avatar

It is hard to make the point perfectly clear. I am not saying take these meds without a diagnosis although I think we will get there. If you have high BP take lisinopril or losartan and or spironolactone or eplerenone. Take a statin for vascular disease or high CV risk. Take metformin for prediabetes or diabetes. Once you have started don't stop

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Kevin's avatar

Thank you!

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Tim Fitzpatrick's avatar

Love this stuff as a 69 year old retired surgeon (post mi with decreased ef from remodeling) If I had studied Zen and gardened more.... Quality as much as quantity of life. Maybe good to keep this in mind. Keep it up please.

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William H Bestermann Jr MD's avatar

Thanks Tim. Your comment means a lot to me. I am an internist. This site is about a longer, healthier life and slowing the remodeling of the heart

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