Aldosterone Blockade Slows CAD and CKD and Blocks the Metabolic Syndrome
williamhbestermannjrmd.substack.com
Dr James Sowers has had a great influence on my thinking. Check out this critical article on the metabolic syndrome and associated diseases. “In the cardiometabolic syndrome there are increased circulating levels of glucocorticoids, which can also activate MR (mineralocorticoid receptor) signaling in cardiovascular, adipose, skeletal muscle, neuronal, and liver tissue. Further, there is increasing evidence that fat tissue produces a lipid soluble factor that stimulates aldosterone production from the adrenal zona glomerulosa. Recently, have we learned that MR blockade improves pancreatic insulin release, insulin-mediated glucose utilization, endothelium-dependent vasorelaxation as well as reducing the progression of CVD and CKD.”
Aldosterone Blockade Slows CAD and CKD and Blocks the Metabolic Syndrome
Aldosterone Blockade Slows CAD and CKD and…
Aldosterone Blockade Slows CAD and CKD and Blocks the Metabolic Syndrome
Dr James Sowers has had a great influence on my thinking. Check out this critical article on the metabolic syndrome and associated diseases. “In the cardiometabolic syndrome there are increased circulating levels of glucocorticoids, which can also activate MR (mineralocorticoid receptor) signaling in cardiovascular, adipose, skeletal muscle, neuronal, and liver tissue. Further, there is increasing evidence that fat tissue produces a lipid soluble factor that stimulates aldosterone production from the adrenal zona glomerulosa. Recently, have we learned that MR blockade improves pancreatic insulin release, insulin-mediated glucose utilization, endothelium-dependent vasorelaxation as well as reducing the progression of CVD and CKD.”