Most clinical trials of medications are short-six months to four years. The one that compares optimal medical treatment (OMT) for type 2 diabetes vs usual care for 21 years shows small differences at first that dramatically increases over time. Excess food keeps mTOR switched on and AMPK switched off for decades. OMT blocks those changes and produces more benefit than any single intervention. What do you think?
We need multi-generational studies, but this runs afoul of short term capitalism in the health care and pharmaceutical industries, and perhaps afoul of Western culture at large.
We should compare diabetic populations on OMT vs those in usual care in big data for years. That will more accurately reflect the benefits of treatment in the real world. New medications should be tested against a background of OMT. Only then can we be certain they provide additional benefit.
Yes, however, alternatives such as intermittent fasting plus lifestyle optimization with proper support are just as effective.
We need multi-generational studies, but this runs afoul of short term capitalism in the health care and pharmaceutical industries, and perhaps afoul of Western culture at large.
We should compare diabetic populations on OMT vs those in usual care in big data for years. That will more accurately reflect the benefits of treatment in the real world. New medications should be tested against a background of OMT. Only then can we be certain they provide additional benefit.