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I am curious about the relationship of the MC4R coded receptor and leptin genetics

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Thanks Owen. That is something that I just don't know about. There is a relation between leptin and that receptor.

https://www.nature.com/articles/s41366-020-00675-4#:~:text=The%20melanocortin%2D4%20receptor%20(MC4R,homeostasis%20%5B1%2C%202%5D.

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Melanacortin receptor as coded for by MC4R the gene predicts general weight gain but also susceptibility to Antipsychotic induced massive weight gain (along with the 5htc3 and DRD2) receptors. There is some decent work from Hillside hospital back in the day on this topic.

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Thanks Owen. I am an internist who has been at it a long time. We are learning more and more about how all illness is related. The distinction between mental and physical illness is entirely artificial. We are learning enough about epigenetics and molecular biology to make primary care much more effective.

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Dammit. This is probably gonna be another article. OK. Thank you.

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Jan 25Liked by William H Bestermann Jr MD

Shared to Natural Health group on TS.

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Thanks

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Nov 19, 2023Liked by William H Bestermann Jr MD

Excellent summary of an important topic . Thank you .

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Great to hear from you

Bill

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