This is amazing information. I would imagine - in fact I believe there are studies - showing that strong early intervention often has powerful long-term effects - say in having a great Grade One experience, have lifelong effects. I remember one study of the outcome for children of having a specific Grade One teacher in a low-income low-education environment in Montreal. Children with other Grade One teachers in that school hardly ever went on to university. 40% of the students in her classes went to university. I remember that she taught the children what most teachers would not approach, even about art appreciation, until high school, if then. She treated them as smart and education as wonderful. Clearly i was very impressed by the study (which I read and let go) and the teacher.
I know that laymen can understand this stuff that I write about and it can make such a difference in the length of their healthy lives. The new understandings of epigenetics and molecular biology are very powerful.
Thank you I did hear of a book called "The Diabetes Code". Again treating diabetes with intermittent fasting and improved diet. Lifestyle changes. Excellent article and topic.
Diet, exercise, and intermittent fasting are excellent interventions that switch off mTOR and switch on AMPK. Precision medicine choices also reduce heart attacks and strokes. Most patients don't receive best practice medical treatment.
Is targeting sugar the best and the ONLY way to control diabetes using Insulin? We may never know because no one asks questions and seeks justifications for that claim.
If you have type 1 diabetes, you don't make enough insulin and the key is to match natural insulin supply against food intake as closely as possible as with an insulin pump and continuous glucose monitoring. Early in the disease, patients with type 2 diabetes are entirely different. They are insulin resistant with high insulin levels. Our approach here is not centered on glucose. It is centered on weight and blocking the effects of genes that are inappropriately switched on. We restrict carbs and sugar and encourage people to eat real, whole food. If metformin is not enough to achieve good sugar management, we add a drug like Jardiance. If the sugar is still too high, we add just enough self adjusted long-acting insulin to get the fasting sugar under 120. We pay equal attention to cholesterol and blood pressure.
Yes, as I mentioned, why not start targeting the nutrient-sensing pathways first, earlier rather than later? Since we know that Indulin promotes cancer???
Yes, the “new science” partially addresses the epigenetic nutrient sensing targets. However, we can not ignore the long-term negative impact of insulin either, Bill. Does it contribute to more cancer and other chronic diseases?
That is a good observation. Overweight people have elevated insulin levels. Insulin is a growth factor that can be substituted for EGFR. EGFR and all of the boxes downstream are cancer causing genes. High insulin levels in overweight patients accelerate aging, chronic disease development, and increase cancer risk.
That is right. That is one of the reasons the ACCORD trial failed. Aggressive treatment that included drugs that increase insulin levels and insulin itself killed more people. Insulin is like Goldilock's porridge. Too much drives accelerated aging and chronic disease development.
Again, the question is, “Is targeting sugar the best and the ONLY way to control diabetes using Insulin?” We may never know because no one asks questions and seeks justifications for that claim. What if we start with controlling the mTOR pathway to protect the end organs first, without pouring insulin into the patients??? The false alarm on “ketogenic shock” must be reexamined with objective empirical evidence without the exaggerated alarmism to promote insulin!
Absolutely. The diagram with the red and green boxes represents core epigenetic changes that drive cancer developmentment and more rapid aging as well as other chronic diseases. Stress increases cortisol levels which switch on the MR receptor just like aldosterone. It is all tied together.
Bill is on the right track and I agree with much that he says. First of all recall that type 1 diabetes is a small portion of the diabetes universe. Type 2 diabetes is the vast majority and it is primarily weight related. Personally I also feel that milk products are provocative for the development of diabetes. I definitely agree with beginning metformin in either type I or type 2 diabetes. Second choice such as Jardiance or Farxiga is the next step, as Bill says. The A1c should be about 4.4 up to age 44 and not above 6.2 at age 62 or thereafter. Risk for cardiovascular complications from diabetes occurs if the 1 hour postprandial is above 155 or the 2 hour is above 83: Those are the numbers where "risk regresses to zero". Obtaining such numbers is difficult. Even the most careful may have difficulty achieving those values: can be done naturally and meds where necessary. My third choice for treatment is definitely NOT insulin but is Ozempic or Mounjaro--EVEN if the diabetic is on insulin. I would not give the latter 2 if the percent body fat was below 23. I am looking forward to the new once a week insulin format. Other risk factors also need to be aggressively addressed with a BP under 125/80, a non-HDL cholesterol of 90 or less, triglycerides 100 or less, CRP 1.0 or less,....
This is amazing information. I would imagine - in fact I believe there are studies - showing that strong early intervention often has powerful long-term effects - say in having a great Grade One experience, have lifelong effects. I remember one study of the outcome for children of having a specific Grade One teacher in a low-income low-education environment in Montreal. Children with other Grade One teachers in that school hardly ever went on to university. 40% of the students in her classes went to university. I remember that she taught the children what most teachers would not approach, even about art appreciation, until high school, if then. She treated them as smart and education as wonderful. Clearly i was very impressed by the study (which I read and let go) and the teacher.
I know that laymen can understand this stuff that I write about and it can make such a difference in the length of their healthy lives. The new understandings of epigenetics and molecular biology are very powerful.
Thank you I did hear of a book called "The Diabetes Code". Again treating diabetes with intermittent fasting and improved diet. Lifestyle changes. Excellent article and topic.
Diet, exercise, and intermittent fasting are excellent interventions that switch off mTOR and switch on AMPK. Precision medicine choices also reduce heart attacks and strokes. Most patients don't receive best practice medical treatment.
Is targeting sugar the best and the ONLY way to control diabetes using Insulin? We may never know because no one asks questions and seeks justifications for that claim.
If you have type 1 diabetes, you don't make enough insulin and the key is to match natural insulin supply against food intake as closely as possible as with an insulin pump and continuous glucose monitoring. Early in the disease, patients with type 2 diabetes are entirely different. They are insulin resistant with high insulin levels. Our approach here is not centered on glucose. It is centered on weight and blocking the effects of genes that are inappropriately switched on. We restrict carbs and sugar and encourage people to eat real, whole food. If metformin is not enough to achieve good sugar management, we add a drug like Jardiance. If the sugar is still too high, we add just enough self adjusted long-acting insulin to get the fasting sugar under 120. We pay equal attention to cholesterol and blood pressure.
Yes, as I mentioned, why not start targeting the nutrient-sensing pathways first, earlier rather than later? Since we know that Indulin promotes cancer???
Well, intermittent fasting, and ketogenic eating, lower the sugar intake naturally, without the need for extra insulin.
Yes, the “new science” partially addresses the epigenetic nutrient sensing targets. However, we can not ignore the long-term negative impact of insulin either, Bill. Does it contribute to more cancer and other chronic diseases?
That is a good observation. Overweight people have elevated insulin levels. Insulin is a growth factor that can be substituted for EGFR. EGFR and all of the boxes downstream are cancer causing genes. High insulin levels in overweight patients accelerate aging, chronic disease development, and increase cancer risk.
Thank you. That’s the conundrum we have faced. Pushing Insulin relentlessly regardless the obvious pitfalls is problematic to some of us.
That is right. That is one of the reasons the ACCORD trial failed. Aggressive treatment that included drugs that increase insulin levels and insulin itself killed more people. Insulin is like Goldilock's porridge. Too much drives accelerated aging and chronic disease development.
Look at the book The Diabetes Code who claims we can reverse diabetes type II he really challenges the status quo.
Again, the question is, “Is targeting sugar the best and the ONLY way to control diabetes using Insulin?” We may never know because no one asks questions and seeks justifications for that claim. What if we start with controlling the mTOR pathway to protect the end organs first, without pouring insulin into the patients??? The false alarm on “ketogenic shock” must be reexamined with objective empirical evidence without the exaggerated alarmism to promote insulin!
I wonder if the sugar plus being overweight contributes to cancer plus stress.
Absolutely. The diagram with the red and green boxes represents core epigenetic changes that drive cancer developmentment and more rapid aging as well as other chronic diseases. Stress increases cortisol levels which switch on the MR receptor just like aldosterone. It is all tied together.
Well, intermittent fasting, and ketogenic eating, lower the sugar intake naturally, without the need for extra insulin.
Bill is on the right track and I agree with much that he says. First of all recall that type 1 diabetes is a small portion of the diabetes universe. Type 2 diabetes is the vast majority and it is primarily weight related. Personally I also feel that milk products are provocative for the development of diabetes. I definitely agree with beginning metformin in either type I or type 2 diabetes. Second choice such as Jardiance or Farxiga is the next step, as Bill says. The A1c should be about 4.4 up to age 44 and not above 6.2 at age 62 or thereafter. Risk for cardiovascular complications from diabetes occurs if the 1 hour postprandial is above 155 or the 2 hour is above 83: Those are the numbers where "risk regresses to zero". Obtaining such numbers is difficult. Even the most careful may have difficulty achieving those values: can be done naturally and meds where necessary. My third choice for treatment is definitely NOT insulin but is Ozempic or Mounjaro--EVEN if the diabetic is on insulin. I would not give the latter 2 if the percent body fat was below 23. I am looking forward to the new once a week insulin format. Other risk factors also need to be aggressively addressed with a BP under 125/80, a non-HDL cholesterol of 90 or less, triglycerides 100 or less, CRP 1.0 or less,....