Is there a minimum recommended dose that would give the “non diabetes” effects of metformin? Ie. the dose one could use for the ancillary effects in à non diabetic patient?
Metformin blocks the effects of ADMA. It comes in 500mg tablets. The full dose for type 2 diabetes is 2000 mg a day. Even one tablets would block a substantial amount of ADMA effect. I have prediabetes and I have been taking 500 mg twice a day for 20 years. My next post with help you understand how metformin has the same effect as fasting or a low calorie diet.
Thanks. I am a family physician and very familiar with metformin in the mgmt of diabetes, but didn’t know what you would consider a dose to adequately block ADMA.
We don't measure ADMA levels as a routine medical matter but we do know that levels are elevated in obesity, diabetes, prediabetes etc. Metformin neutralizes ADMA molecule for molecule. I don't think we can know exactly what dose adquately blocks ADMA but we do know that we can lower the impact. This is most likely a receptor blocker type of interference.
I am a 74 y.o. female on Levothyroxine (.88 mcg) for hypothyroidism, and take nothing else except drops for dry eyes and vitamins.
I am overweight at BMI of 31 and struggle to lose weight. My A1C is perpetually in the 5.4 to 5.8 range. I doubt my PCP would give me an RX for Metformin so I wonder how most of us can get access to it, or the Rapamycin mentioned in another post?
I am delighted because you put two chemical structures and explained how the partial similarity between them helps one (Metformin) block the negative effect of the other ( ADMA). I am 80, from India, a PhD, retired industry organic chemistry R&D. For several years now, I took to some reading of medicinal chemistry and drug structures as an interest. When Covid began in 2020, I began following it very keenly, especially trials with repurposed drugs, with whatever reading material I could gain access to. Initially, I found that the successful trails with about 30 repurposed drugs, from many different indications, had a shared structural feature - the nature of the nitrogen atom. As I began writing down the structures of about 700-800 molecules from these indications, like anti histamines, anti biotics, anti inflammatories, immune modulators, respiratory drugs, anti psychotic drugs etc, I found all most all of them had this basic nitrogen feature ( mostly amine type). Based on simple electrostatic interactions between molecules, I could see easily how they would deactivate the virus spike protein. In other words, we had hundreds of anti virals ( additional feature) out of a good pharmacy stock. I have espoused this view in many places, by way of comments. For example, it was known that 80% of the 2500 odd drug molecules in use since decades had nitrogen in their structure. Out of these, if 80% had basic type of nitrogens ( pKa 7.5/8 plus), we have about 1600 drug molecules in known use to be additionally anti viral. Much before Covid, people have looked at them as Cationic Amphiphilic Drugs ( CADs) capable of anti viral properties against corona viruses, the CAD being a chemical structure feature. Though I got dozens and dozens of appreciative responses, I remember only one backing my chemical structure emphasis. It is chemistry (chemical structure) that drives biology. Incidentally, when I was busy with these thoughts in 2021 and early 2022, I came across a paper that computer scanned about 2000 drug molecules using standard software and claimed that about 1500 could be effective in Covid. This was a revelation, unfortunately I lost track of that reference. I felt vindicated. I am also on diabetic medication for the past 15 years, with 2 X 500 mg of Metformin a day since the beginning, with additional Glimepiride in the first few years, Voglibose for 2-3 years and with Gliptins for the past 5 years. I have some doubts, which I will check with you shortly. I can do it here or on your mail. Please let me know. Mine is balakrishnan.moro@gmail.com
Is there a minimum recommended dose that would give the “non diabetes” effects of metformin? Ie. the dose one could use for the ancillary effects in à non diabetic patient?
Metformin blocks the effects of ADMA. It comes in 500mg tablets. The full dose for type 2 diabetes is 2000 mg a day. Even one tablets would block a substantial amount of ADMA effect. I have prediabetes and I have been taking 500 mg twice a day for 20 years. My next post with help you understand how metformin has the same effect as fasting or a low calorie diet.
Thanks. I am a family physician and very familiar with metformin in the mgmt of diabetes, but didn’t know what you would consider a dose to adequately block ADMA.
We don't measure ADMA levels as a routine medical matter but we do know that levels are elevated in obesity, diabetes, prediabetes etc. Metformin neutralizes ADMA molecule for molecule. I don't think we can know exactly what dose adquately blocks ADMA but we do know that we can lower the impact. This is most likely a receptor blocker type of interference.
I’m sure. Thank you. I suspect 250-500 mg/day would suffice.
I am a 74 y.o. female on Levothyroxine (.88 mcg) for hypothyroidism, and take nothing else except drops for dry eyes and vitamins.
I am overweight at BMI of 31 and struggle to lose weight. My A1C is perpetually in the 5.4 to 5.8 range. I doubt my PCP would give me an RX for Metformin so I wonder how most of us can get access to it, or the Rapamycin mentioned in another post?
I am delighted because you put two chemical structures and explained how the partial similarity between them helps one (Metformin) block the negative effect of the other ( ADMA). I am 80, from India, a PhD, retired industry organic chemistry R&D. For several years now, I took to some reading of medicinal chemistry and drug structures as an interest. When Covid began in 2020, I began following it very keenly, especially trials with repurposed drugs, with whatever reading material I could gain access to. Initially, I found that the successful trails with about 30 repurposed drugs, from many different indications, had a shared structural feature - the nature of the nitrogen atom. As I began writing down the structures of about 700-800 molecules from these indications, like anti histamines, anti biotics, anti inflammatories, immune modulators, respiratory drugs, anti psychotic drugs etc, I found all most all of them had this basic nitrogen feature ( mostly amine type). Based on simple electrostatic interactions between molecules, I could see easily how they would deactivate the virus spike protein. In other words, we had hundreds of anti virals ( additional feature) out of a good pharmacy stock. I have espoused this view in many places, by way of comments. For example, it was known that 80% of the 2500 odd drug molecules in use since decades had nitrogen in their structure. Out of these, if 80% had basic type of nitrogens ( pKa 7.5/8 plus), we have about 1600 drug molecules in known use to be additionally anti viral. Much before Covid, people have looked at them as Cationic Amphiphilic Drugs ( CADs) capable of anti viral properties against corona viruses, the CAD being a chemical structure feature. Though I got dozens and dozens of appreciative responses, I remember only one backing my chemical structure emphasis. It is chemistry (chemical structure) that drives biology. Incidentally, when I was busy with these thoughts in 2021 and early 2022, I came across a paper that computer scanned about 2000 drug molecules using standard software and claimed that about 1500 could be effective in Covid. This was a revelation, unfortunately I lost track of that reference. I felt vindicated. I am also on diabetic medication for the past 15 years, with 2 X 500 mg of Metformin a day since the beginning, with additional Glimepiride in the first few years, Voglibose for 2-3 years and with Gliptins for the past 5 years. I have some doubts, which I will check with you shortly. I can do it here or on your mail. Please let me know. Mine is balakrishnan.moro@gmail.com