The last post discussed the key role of metabolic memory and chronic diseases, and how we can use that new information to prolong healthy life. Many of you know about oxidants as a cause of faster aging and more rapid chronic disease development. Some of you took vitamin E, a known antioxidant, but later studies proved that vitamin E was not helpful. You were on the right track. Medications like lisinopril or
While this is an absolute excellent post , the vitamin E research I believe you are citing was extremely flawed . The researchers use only alpha -tocopherol , which lowers the delta and gamma tocipherols , which are cardio protective . The results of this research have deprived many of an important anti-oxidant. Let’s hope they are getting some lipoic acid somewhere to help recycle their available e ( and c).
Thank you for all the effort in above article . I will print and study .
I use NAC at times (4800) short term to help control mTor .
Insulin and insulin related growth factor are both growth factors that can be substituted for EGFR in the purple box in the diagram. Insulin switches on mTOR and switches off AMPK. Therefore, the abnormally high insulin levels of prediabetes and early type 2 diabetes cause disease. We do everything we can minimize insulin levels in the blood. Carb restriction, sugar restrictiion, exercise, metformin, and SGLT 2 inhibitors or GLP1 agonists. Only if those measures fail do we give self-adjusted insulin to keep the fasting sugar under 120. If patients cut way back on carbs and sugar we can usually avoid insulin. Intermittent fasting switches on AMPK and switches off mTOR. Stress causes increases cortisol levels. Cortisol switches on the same MR receptor as aldosterone. Stress switches on mTOR and switches off AMPK. That is how it is all tied together--epigenetics and molecular biology.
It would help if you created An alternative parallel to the one you are using to ensure we don't mislead people that these ARE yet. The story is much more complex than we believe, Bill.
You are right. Any growth factor can be put in the purple box instead of the epidermal growth factor receptor. There are at least 25 different ones VEGF, PDGF, HGF, insulin, IGF-1 etc.
Sorry about that. It is a complex topic--sort of a unifying hypothesis of aging and chronic disease that can lead to more effective choices. If is hard to explain in a shorter format. I did highlight key points if that works better for you
While this is an absolute excellent post , the vitamin E research I believe you are citing was extremely flawed . The researchers use only alpha -tocopherol , which lowers the delta and gamma tocipherols , which are cardio protective . The results of this research have deprived many of an important anti-oxidant. Let’s hope they are getting some lipoic acid somewhere to help recycle their available e ( and c).
Thank you for all the effort in above article . I will print and study .
I use NAC at times (4800) short term to help control mTor .
The good news is that the medications and lifestyle measures I am describing are proven to prolong healthy life. They are inexpensive and easy to use.
Your post convinced me to become a paid prescriber . Lo and behold , I already was !!
I love it ! Thank you !
Where does insulin fit in all this complexity? What about fasting and exercise? Stress reduction?
Insulin and insulin related growth factor are both growth factors that can be substituted for EGFR in the purple box in the diagram. Insulin switches on mTOR and switches off AMPK. Therefore, the abnormally high insulin levels of prediabetes and early type 2 diabetes cause disease. We do everything we can minimize insulin levels in the blood. Carb restriction, sugar restrictiion, exercise, metformin, and SGLT 2 inhibitors or GLP1 agonists. Only if those measures fail do we give self-adjusted insulin to keep the fasting sugar under 120. If patients cut way back on carbs and sugar we can usually avoid insulin. Intermittent fasting switches on AMPK and switches off mTOR. Stress causes increases cortisol levels. Cortisol switches on the same MR receptor as aldosterone. Stress switches on mTOR and switches off AMPK. That is how it is all tied together--epigenetics and molecular biology.
It would help if you created An alternative parallel to the one you are using to ensure we don't mislead people that these ARE yet. The story is much more complex than we believe, Bill.
You are right. Any growth factor can be put in the purple box instead of the epidermal growth factor receptor. There are at least 25 different ones VEGF, PDGF, HGF, insulin, IGF-1 etc.
Yup. These are the variations of a same theme.
No executive summary!?
Sorry about that. It is a complex topic--sort of a unifying hypothesis of aging and chronic disease that can lead to more effective choices. If is hard to explain in a shorter format. I did highlight key points if that works better for you
Thanks. Your support makes a big difference