Scientific proof exists that optimal medical therapy (OMT)can extend healthier human life by 8 years now. In the last post there was a podcast from Dr Peter Attia with Dr. David Sabatini and Dr Matt Kaeberlein. Dr. Matt Kaeberlein on that wonderful podcast discussed a study in dogs designed to show a 9% longevity increase due to inhibiting the mechanistic target of rapamycin (mTOR) with rapamycin. mTOR is a master metabolic genetic switch that coordinates food availability with growth rates in the fetus and child. Activating mTOR later in life makes us age faster and get sick sooner. There is a study in humans with type 2 diabetes and chronic kidney disease that provides 21 years of follow-up. The average age of entry into the human
So does vitamin E but clinical trials proved that giving it in pill form did not improve healthspan. There are multiple meds that are antioxidants that are proven to extend healthspan at lower cost. Proof is the key.
I'm a physical therapist, studied medicine, then taught myself coding and am now analyzing data. Pharmacology has been a passion since my youth, so I acquired 99% of my knowledge outside of university.
Been receiving financing for the analysis, so I could really focus on the data for quite some time now. Writing an article about the US situation. Short version: The vaccines seem to have been causing disease enhancement in freshly first-dosed individuals in the USA during Delta.
Thank you. Such valuable information on quality of lives and reasonable common sense often lacking today. People want choices and information let’s hope we all can enlighten.
Oct 11, 2023·edited Oct 11, 2023Liked by William H Bestermann Jr MD
This seems very muddy to my mind. From what I can tell Steno-2 appears to be a basic health intervention. It doesn't mention mTOR or rapamycin.
Does anyone know for sure what they're doing with mTOR/rapa? You can't just shut if off completely, it's a necessary pathway, and there may well be serious problems in blunting it too much. Most people who use it take this modest protocol of once a week. Is that extrapolated from the mouse stuff ?
The article says exercise deactivates mTOR, but exercises activates mTOR is my understanding.
There's a lot of talk about antioxidants. It's a very general term. I'm not up to speed on the specific chemistry, but does an antioxidant effect form a significant part of losartan or a statin's therapeutic effect or mechanism of action? Downstream maybe I suppose some argument could be made tenuously. It's a rather confusing term.
Most people wouldn't want to touch a drug like spironolactone. And it seems doubtful now non-diabetics should touch metformin.
For people who are metabolically compromised with obesity, diabetes and so on it's a different story
The Steno 2 protocol is over 20 years old. The drugs were chosen for the protocol because they produced more benefit than lowering the target risk factor. Losartan and lisinopril for hypertension, statins for chrolesterol, and metformin reduce oxidant production precisely and reduce epidermal growth factor receptor activation. The epidermal growth factor receptor switches on mTOR and switches off AMPK which have a reciprocal relationship. Metformin also directly switches off mTOR and switches on AMPK. You are correct. mTOR and AMPK work less like regular switches and more like dimmer switches. We are not completely switching off mTOR and switching on AMPK. The Steno 2 protocol did not use rapamycin and it does not mention mTOR, but it does produce massively better outcomes and this is the best explanation for the difference between Steno 2 outcomes and the care that most of us receive. Exercise, diet, and intermittent fasting activate AMPK which deactivates mTOR. The antioxidant effect of these drugs are well described. The difference is these are antioxidants that work. Aging is the greatest risk factor for chronic diseases. We produce more oxidants as we age while our antioxidant power deteriorates. This is all that I write about in over 600 posts on Substack and the sources are all linked. Happy to answer any questions that arise.
Very well explained ! Thank you for your great information .
Methylene Blue helps Mitochondria make fewer ROS.
So does vitamin E but clinical trials proved that giving it in pill form did not improve healthspan. There are multiple meds that are antioxidants that are proven to extend healthspan at lower cost. Proof is the key.
Plus Methylene Blue is a MAO-A inhibitor and not a weak one either. Nothing I would blindly recommend to anyone.
What kind of work do you do?
I'm a physical therapist, studied medicine, then taught myself coding and am now analyzing data. Pharmacology has been a passion since my youth, so I acquired 99% of my knowledge outside of university.
Been receiving financing for the analysis, so I could really focus on the data for quite some time now. Writing an article about the US situation. Short version: The vaccines seem to have been causing disease enhancement in freshly first-dosed individuals in the USA during Delta.
You are making a difference. It is great to be in touch with you.
Very useful for me as I take a medication where MAO's are contraindicated!
So thanks!
Happy to hear my smart-assing paid out.
<3
Thank you. Such valuable information on quality of lives and reasonable common sense often lacking today. People want choices and information let’s hope we all can enlighten.
Thanks Laura. I appreciate your help
Excellent article on health. we are starved for information like this. Thank you so much!
Thanks Laura
This seems very muddy to my mind. From what I can tell Steno-2 appears to be a basic health intervention. It doesn't mention mTOR or rapamycin.
Does anyone know for sure what they're doing with mTOR/rapa? You can't just shut if off completely, it's a necessary pathway, and there may well be serious problems in blunting it too much. Most people who use it take this modest protocol of once a week. Is that extrapolated from the mouse stuff ?
The article says exercise deactivates mTOR, but exercises activates mTOR is my understanding.
There's a lot of talk about antioxidants. It's a very general term. I'm not up to speed on the specific chemistry, but does an antioxidant effect form a significant part of losartan or a statin's therapeutic effect or mechanism of action? Downstream maybe I suppose some argument could be made tenuously. It's a rather confusing term.
Most people wouldn't want to touch a drug like spironolactone. And it seems doubtful now non-diabetics should touch metformin.
For people who are metabolically compromised with obesity, diabetes and so on it's a different story
The Steno 2 protocol is over 20 years old. The drugs were chosen for the protocol because they produced more benefit than lowering the target risk factor. Losartan and lisinopril for hypertension, statins for chrolesterol, and metformin reduce oxidant production precisely and reduce epidermal growth factor receptor activation. The epidermal growth factor receptor switches on mTOR and switches off AMPK which have a reciprocal relationship. Metformin also directly switches off mTOR and switches on AMPK. You are correct. mTOR and AMPK work less like regular switches and more like dimmer switches. We are not completely switching off mTOR and switching on AMPK. The Steno 2 protocol did not use rapamycin and it does not mention mTOR, but it does produce massively better outcomes and this is the best explanation for the difference between Steno 2 outcomes and the care that most of us receive. Exercise, diet, and intermittent fasting activate AMPK which deactivates mTOR. The antioxidant effect of these drugs are well described. The difference is these are antioxidants that work. Aging is the greatest risk factor for chronic diseases. We produce more oxidants as we age while our antioxidant power deteriorates. This is all that I write about in over 600 posts on Substack and the sources are all linked. Happy to answer any questions that arise.