18 Comments
May 31Liked by William H Bestermann Jr MD

Cutting, eye-opening content, and courage, always! I cannot express how much I learn from you. I’m excited and thrilled to be promoting optimally medical therapy as a turnkey part of my custom Community-Owned Health Plan. It’ll make a difference in people’s lives, and the employers spend!

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I am equally thrilled to be working with a healthcare consultant who understands the path to better health at lower cost

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May 30Liked by William H Bestermann Jr MD

Great information in this document! Thank you for continuing to post insightful information that helps everyone reading them! You are a valued advocate for us all!

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Great to hear from you Sis!

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May 30Liked by William H Bestermann Jr MD

Great article, and important topic.

My trust in the government is less than zero at the moment, so a “solution” that involves them makes me laugh (even a good solution)

Until our government agencies stop working for big Pharma, big Food, Big Ag, etc. We must take responsibility for our own health. At the same time we definitely should share our concerns with our elected (selected?) folks.

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As you say, we don't have government of, for, and by the people We have government of, for, and by the few wealthy people and corporations. Healthcare is the place where the evidence is the most glaring. The only people who can block ads than make our children sick is the government. That is just the fact and most people just know enough about the mechanics to protect themselves. Most of my patients will change what they are doing if they understand the reasons, the consequences, and the value of change.

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May 30Liked by William H Bestermann Jr MD

It may be the microbiome that has changed. These GLP drugs may not be required if the microbiome is fixed.

https://www.nature.com/articles/s42255-024-01040-9

Agmatine produced by gut microbiota — specifically, Bacteroides vulgatus — activates the farnesoid X receptor (FXR) in intestinal epithelial L cells in a bile-acid-independent manner, which inhibits host glucagon peptide 1 (GLP-1) secretion and leads to polycystic ovary syndrome (PCOS) in mice. Supplementing mice with the GLP-1 receptor (GLP-1R) agonist liraglutide or inhibiting the production of agmatine reverses the PCOS phenotype.

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We may be making this too complicated. Eating whole, real food improves the microbiome. I would much rather eat that food than take some pill to improve my microbiome. The microbiome matters, but by going to healthy food we can manage that too.

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Jun 2Liked by William H Bestermann Jr MD

What I'm saying is your microbiome might be messing up your sensing of nutrients and pushing you to choose foods that are good for junk food manufacturers fixing the original problem will make it simple to eat the way you specify!

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And I am saying the most natural, easy way to fix the problem is to eat whole, real food

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this wont work if your microbiome is telling you to eat unreal calories.

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I love bill's writting. So clear. So crisp.

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Thanks Owen. That is high praise coming from a colleague and fellow Substack author.

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He certainly describes the Hawaiian Punch

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May 30Liked by William H Bestermann Jr MD

Excellent article will share as it touches on so many health aspects and our current state of dysfunctional politics. In the news this week China has reportedly cured diabetes via stem cells. So we really are not leading anymore. https://www.dailymail.co.uk/health/article-13464941/chinese-patient-diabetes-cure-stem-cells.html

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Thanks Laura. I always appreciate your comments.

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The cited “article” describes stem cell treatment of “type2 DM” by restoring insulin producing pancreatic islet cells. While remarkable therapy, restoration of endogenous insulin production is treatment of type1DM (which can develop from type2) and will not cure our “epidemic” of type 2.

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They claim the recipient is in remission

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