This data comes directly from the Medicare system. It compares the rate of chronic illness between Medicare patients and those with both Medicare and Medicaid. And so it compares chronic disease rates between most of us and the poor. These results are very striking to me. The rates of depression and Alzheimer’s disease are doubled.
They are common and devastating as you know. They are just less common than the type 21. I am more and more convinced that excess oxidative particle generation is a common denominator in aging and developing chronic illnesses more rapidly, like Parkinson's.
Thanks for the reply and the link - I will read with interest. On a similar theme, I believe Prof Naviuax's "Cell Danger Response" is involved in conditions like PD, have you come across this before? http://www.outthinkingparkinsons.com/articles/cell-danger-response
Thanks Gary. I reviewed this in detail. I think the speaker is saying that a drop in ATP from the mitochondria is a danger response. It can occur in settings like starvation or low oxygen supply. It activates AMPK which is a key factor in precision medicine and that is a central consideration in all the discussions on my site. Medications like empagliflozin for diabetes activate AMPK also which explains why they lower hospitalizations for congestive heart failure by 30% whether the patient is diabetic or not!
Look up this article in Diabetes Care. "SGLT2 Inhibitors Produce Cardiorenal Benefits by Promoting Adaptive Cellular Reprogramming to Induce a State of Fasting Mimicry: A Paradigm Shift in Understanding Their Mechanism of Action." Sorry about the link.
Great question. You can show the greatest impact quickly on patients with patients with diabetes and a complication like chronic kidney disease. The earlier you start optimal medical therapy the better. In the Steno two trial, at 8 years the difference between usual care and OMT was so great, everyone went on OMT. Even so, because of metabolic memory, the OMT group continued to do much better. If you start in prediabetes you can slow progression dramatically and delay cost
It’s hard to watch patients having to make care choices based on costs. Hopefully the legislation President Biden has been so passionate about will lead to the changes needed.
We must realize that ALL these costly and deadly chronic diseases are absolutely preventable with simple early detection and primary lifestyle optimization prevention measures. This is why we exist to initiate this absolutely essential fundamental transformation needed to save mankind!
Thanks for useful tables. Curious - where are conditions like Parkinson's Disease?
They are common and devastating as you know. They are just less common than the type 21. I am more and more convinced that excess oxidative particle generation is a common denominator in aging and developing chronic illnesses more rapidly, like Parkinson's.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565564/pdf/nihms-420619.pdf
Thanks for the reply and the link - I will read with interest. On a similar theme, I believe Prof Naviuax's "Cell Danger Response" is involved in conditions like PD, have you come across this before? http://www.outthinkingparkinsons.com/articles/cell-danger-response
Thanks Gary. I reviewed this in detail. I think the speaker is saying that a drop in ATP from the mitochondria is a danger response. It can occur in settings like starvation or low oxygen supply. It activates AMPK which is a key factor in precision medicine and that is a central consideration in all the discussions on my site. Medications like empagliflozin for diabetes activate AMPK also which explains why they lower hospitalizations for congestive heart failure by 30% whether the patient is diabetic or not!
https://watermark.silverchair.com/dci190074.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArswggK3BgkqhkiG9w0BBwagggKoMIICpAIBADCCAp0GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMTqSeAW5HflHgQrtRAgEQgIICbrjZtVieoS8WN5iMqDZG4dCOtHoNHLc7Ignvlxg6h6N2OyfgdGYtfqoSiacRlfEkmONkYfJH8MOhoZtxQ08OAG_3ghNB9HxR-LTGHK8jXq2EYlAfJJNhrOBsO2yIg7VzYOB-pKVzkbvYxU6WOURXM90-lpiQrhcj4j8LmgBtkqSCv1KbvUzF-q2b2DS8gqnMNQvoy_4KxGKrfDj2Z2OVRFWzLuzBJp3NKBPS_2QNe1KWjVxZezxH0KgWBDeqZidcg1WxRH2oGatQqwZBTCVgssPlABZTnSZUbzQwge52k5qDA0TeMDaRfI_--jFuAZuqsr80W-nGUUfVomx8DAhB9z7am5uijrRCHu_ppCrGmqYI28bE44eBW3sKdrPsA9VOQd9FQgvzbBvl6ZGO5UiPqLA7Gt03kPgxigVRuRnhWRfLvk6vfQYfi8g9exEgcT1BkpM_HeUN7PdXgeksGC-ivClQ_UjwmQBFZ_CK7C4u2ye_itKLueUIbO1y2hGaGALaBphg3tWC9IJkjYrsl8X8ZX1-igjWz6qg4OTrImUaORY4uC91Lly0FEN1Y6Y0ZgsprETnq9TlLz9R_ZPiipXMpjIfyHtnJ4nxKFAvE-qa5lWW8yj-u75hPcOosLSIvBi_6jmrwp_QOp448v7HDcOKmOeNyIDtNzbjFHKmnkTHp_FM-X9vqbNrtmTTHzIP69VsWKzC-jgQeT9ELfPUNEMRTs07pxYAlHQWiAebd2nbwu2uxx4XupagheOEmHRK9HVVXHY_TwtDepGfAJRp0g_RHFpyYQDg7ifHUAsthAt24QFzMNq9-krUiqG1wcg1yy4
Thanks, I will in turn delve in to your work. ps the link isn't working - it is saying something about "token expired"?
Look up this article in Diabetes Care. "SGLT2 Inhibitors Produce Cardiorenal Benefits by Promoting Adaptive Cellular Reprogramming to Induce a State of Fasting Mimicry: A Paradigm Shift in Understanding Their Mechanism of Action." Sorry about the link.
Would earlier diagnosis impact cost of care. For example, the largest cost; diabetes?
Great question. You can show the greatest impact quickly on patients with patients with diabetes and a complication like chronic kidney disease. The earlier you start optimal medical therapy the better. In the Steno two trial, at 8 years the difference between usual care and OMT was so great, everyone went on OMT. Even so, because of metabolic memory, the OMT group continued to do much better. If you start in prediabetes you can slow progression dramatically and delay cost
It’s hard to watch patients having to make care choices based on costs. Hopefully the legislation President Biden has been so passionate about will lead to the changes needed.
Great to hear from you. We can do better and we should
We must realize that ALL these costly and deadly chronic diseases are absolutely preventable with simple early detection and primary lifestyle optimization prevention measures. This is why we exist to initiate this absolutely essential fundamental transformation needed to save mankind!
https://mcgdoc76e.substack.com/p/a-real-21st-tricorder-the-multifunction?r=q7iae&s=w&utm_campaign=post&utm_medium=web
https://mcgdoc76e.substack.com/p/what-is-mcg?r=q7iae&s=w&utm_campaign=post&utm_medium=web&utm_source=direct This is the work of two generations of mathematicians, physicians, computer/ML/AI engineers and more than two decades of hard and determined missionary work! Thank Jesus, we succeeded and continued to thrive!