Each puff of cigarette smoke contains 10 to the fifteenth oxidative particles. That is equivalent to the number of ants on the planet. Burning is an oxidative process. Any smoke produced by burning anything has large numbers of oxidative particles. That is why diesel exhaust is a health hazard and marijuana smoke does contain oxidants also. Burning anything and inhaling damages cells and organs. We cannot avoid all but deliberately inhaling it is not a good idea.
Hey Bill, is this a misstatement? “ It acts directly on the amino acid sensing mechanism that switches on mTOR and switches off AMPK.” Or the opposite happens?
So it is a competitive inhibition for both mechanisms; one is an off switch for mTOR by shutting off the activation, and the other is an on switch for AMPK by removing the inhibition. One stone two birds. Perfect!
ADMA is an amino acid that engages a lysosomal transceptor (transporter and receptor) which switches on mTOR and switches off AMPK. Metformin precisely blocks ADMA engagement with the transceptor to switch off mTOR and switch on AMPK. That is how metformin protects cells and organs
How about marijuana, a few puffs a day for sleep aid? Just as bad as cigarettes?
Each puff of cigarette smoke contains 10 to the fifteenth oxidative particles. That is equivalent to the number of ants on the planet. Burning is an oxidative process. Any smoke produced by burning anything has large numbers of oxidative particles. That is why diesel exhaust is a health hazard and marijuana smoke does contain oxidants also. Burning anything and inhaling damages cells and organs. We cannot avoid all but deliberately inhaling it is not a good idea.
https://www.atsjournals.org/doi/full/10.1165/ajrcmb.20.6.3424#:~:text=Alveolar%20macrophages%20obtained%20from%20habitual,in%20the%20lungs%20of%20smokers.
Hey Bill, is this a misstatement? “ It acts directly on the amino acid sensing mechanism that switches on mTOR and switches off AMPK.” Or the opposite happens?
The amino acid switching mechanism switches on mTOR and switches off AMPK. Metformin blocks the amino acid sensing mechanism. Sorry it was confusing.
So it is a competitive inhibition for both mechanisms; one is an off switch for mTOR by shutting off the activation, and the other is an on switch for AMPK by removing the inhibition. One stone two birds. Perfect!
ADMA is an amino acid that engages a lysosomal transceptor (transporter and receptor) which switches on mTOR and switches off AMPK. Metformin precisely blocks ADMA engagement with the transceptor to switch off mTOR and switch on AMPK. That is how metformin protects cells and organs