This short piece with links may be useful if you are trying to get across the science and systems of optimal medical therapy for chronic disease in a short period of time.
Metformin directly switches off mTOR. Metformin directly switches on AMPK. Lisinopril, losartan, statins, and spironolactone indirectly switch off mTOR and switch on AMPK. When you combine these medications with diet and exercise in an optimal medical therapy (OMT) protocol there are dramatic impacts on cardiovascular mortality, all-cause mortality and costs. A multidisciplinary team provides OMT more effectively. We can provide longer, healthier lives at lower cost now.
We can help to measure the degree of functional improvement or impairment objectively and mathematically to ensure that one is headed to right direction!