Yesterday we discussed the critical role of angiotensin II and aldosterone in diabetic kidney damage that leads to dialysis. New science has broadened our understanding and it appears that the same same signaling is involved in kidney failure due to hypertension as well. As you can see from the diagram, both angiotensin II and aldosterone increase oxidant production, but so does the enzyme that makes bad cholesterol (HMG CoA Reductase) and cigarette smoke. The oxidants from all these factors activate the
Yup!