This article connected the dots linking cardiovascular disease, cancer, and aging with the molecular biology that causes them. I already had some knowledge of mTOR, AMPK, and oxidants, but this article brought it all together. Abdominal fat make excess aldosterone leading to oxidant production, epidermal growth factor activation , and ultimately switches on mTOR and switches off AMPK. What do you think?
Aldosterone in the red box in the upper right corner is a hormone that is produced in abdominal fat in overweight individuals. It activates a receptor on the cell surface that increases oxidant production. Those oxidants activate the epidermal growth factor receptor (EGFR) which in turn activates mTOR which causes scar tissue formation. That is a fundamental part of kidney damage. That sequence of events is involved in most cardiovascular disease and related conditions. The red boxes all add to that signaling and the green block interventions block it.
The article is too technical to understand. Please interpret.
Aldosterone in the red box in the upper right corner is a hormone that is produced in abdominal fat in overweight individuals. It activates a receptor on the cell surface that increases oxidant production. Those oxidants activate the epidermal growth factor receptor (EGFR) which in turn activates mTOR which causes scar tissue formation. That is a fundamental part of kidney damage. That sequence of events is involved in most cardiovascular disease and related conditions. The red boxes all add to that signaling and the green block interventions block it.